Prevention of diabetes-induced microangiopathy by human tissue kallikrein gene transfer.

@article{Emanueli2002PreventionOD,
  title={Prevention of diabetes-induced microangiopathy by human tissue kallikrein gene transfer.},
  author={Costanza Emanueli and Maria Bonaria Salis and Alessandra Pinna and Tiziana Stacca and Anna Franca Milia and Alessandra Spano and Julie Chao and Lee Chao and Luigi Sciola and Paolo Madeddu},
  journal={Circulation},
  year={2002},
  volume={106 8},
  pages={993-9}
}
BACKGROUND Microvascular insufficiency represents a major cause of end-organ failure among diabetics. METHODS AND RESULTS In streptozotocin-induced diabetic mice, we evaluated the potential of human tissue kallikrein (hTK) gene as a sole therapy against peripheral microangiopathy. Local delivery of hTK gene halted the progression of microvascular rarefaction in hindlimb skeletal muscle by inhibiting apoptosis, thus ensuring an improved hemodynamic recovery in case of supervening vascular… CONTINUE READING

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