Prevention of diabetes in NOD mice at a late stage by targeting OX40/OX40 ligand interactions.

Abstract

Autoreactive T cells play a major role in the development of insulin-dependent diabetes mellitus, suggesting that costimulatory molecules that regulate T cell responses might be essential for disease progression. In NOD mice, CD28/B7 and CD40/CD40 ligand (L) interactions control the onset of diabetes from 2 to 4 weeks of age, but blocking these molecules… (More)

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Cite this paper

@article{Pakala2004PreventionOD, title={Prevention of diabetes in NOD mice at a late stage by targeting OX40/OX40 ligand interactions.}, author={Syamasundar V. Pakala and Pratima Bansal-Pakala and Beth S. Halteman and Michael Croft}, journal={European journal of immunology}, year={2004}, volume={34 11}, pages={3039-46} }