Prevention of cytotoxicity of nickel by quercetin: the role of reactive oxygen species and histone acetylation.

Abstract

Excessive exposure to nickel may cause health effects on the blood, lung, nose, kidney, reproductive system, skin and the unborn child. In the present study, we found that Ni²⁺ exposure led to a time- and dose-dependent proliferation arrest and death in human leukemia HL-60 cells. In the presence of 1 mM Ni²⁺, reactive oxygen species (ROS) generation… (More)
DOI: 10.1177/0748233711433940

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