Prevention of complement-induced pulmonary hypertension and improvement of right ventricular function by selective thromboxane receptor antagonism.

@article{Smith1994PreventionOC,
  title={Prevention of complement-induced pulmonary hypertension and improvement of right ventricular function by selective thromboxane receptor antagonism.},
  author={W. Johnson Smith and Michael P Murphy and Robert F. Appleyard and Robert J Rizzo and Lishan Aklog and Rita G. Laurence and Lawrence Harvey Cohn},
  journal={The Journal of thoracic and cardiovascular surgery},
  year={1994},
  volume={107 3},
  pages={800-6}
}
The effect of complement activation on the pulmonary vascular system and on right ventricular function was studied in sheep (n = 12) by injection of cobra venom factor. Animals were instrumented for measurement of pulmonary flow, mean pulmonary artery pressure, right ventricular stroke work, arterial blood gases, and systemic vascular resistance. Blood was sampled from the left atrium and pulmonary artery to measure thromboxane B2, the metabolite of thromboxane A2, by radioimmunoassay. After… CONTINUE READING