Prevention of colitis-associated cancer by selective targeting of immunoproteasome subunit LMP7

@inproceedings{Vachharajani2017PreventionOC,
  title={Prevention of colitis-associated cancer by selective targeting of immunoproteasome subunit LMP7},
  author={Niyati Vachharajani and Thorsten Joeris and Maik Luu and Sabrina Hartmann and Sabine Pautz and Elena Jenike and Georgios Pantazis and Immo Prinz and Markus J Hofer and Ulrich Steinhoff and Alexander Visekruna},
  booktitle={Oncotarget},
  year={2017}
}
Chronic inflammation is a well-known risk factor in development of intestinal tumorigenesis, although the exact mechanisms underlying development of colitis-associated cancer (CAC) still remain obscure. The activity and function of immunoproteasome has been extensively analyzed in the context of inflammation and infectious diseases. Here, we show that the proteasomal immunosubunit LMP7 plays an essential role in development of CAC. Mice devoid of LMP7 were resistant to chronic inflammation and… CONTINUE READING

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