Prevention of cold ischaemia-reperfusion injury by an endothelin receptor antagonist in experimental renal transplantation.

@article{Herrero1999PreventionOC,
  title={Prevention of cold ischaemia-reperfusion injury by an endothelin receptor antagonist in experimental renal transplantation.},
  author={Ignacio Herrero and Juan Torras and Marta Riera and Enric Condom and Oriol Coll and Josep Mar{\'i}a Cruzado and Miguel Hueso and Jordi Bover and N{\'u}ria Lloberas and J. Alsina and Josep Mar{\'i}a Grinyo},
  journal={Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association},
  year={1999},
  volume={14 4},
  pages={872-80}
}
BACKGROUND Endothelin (ET) is known to play a role in the pathogenesis of warm ischaemic renal damage, however, little is known about its involvement in renal cold ischaemia. This study was designed to investigate the response of ET after kidney cold ischaemia, and to assess the potential protective effect of bosentan, a dual, non-selective ET(A)/ET(B) receptor antagonist, against cold ischaemia reperfusion injury in a rat model of syngeneic renal transplantation. METHODS Kidneys from Lewis… CONTINUE READING