Prevention of cholesterol gallstones by inhibiting hepatic biosynthesis and intestinal absorption of cholesterol.

@article{Wang2013PreventionOC,
  title={Prevention of cholesterol gallstones by inhibiting hepatic biosynthesis and intestinal absorption of cholesterol.},
  author={Helen Wang and Piero Portincasa and Ornella de Bari and Kristina J. Liu and Gabriella Garruti and Brent A Neuschwander-Tetri and David Q-H Wang},
  journal={European journal of clinical investigation},
  year={2013},
  volume={43 4},
  pages={413-26}
}
BACKGROUND Cholesterol cholelithiasis is a multifactorial disease influenced by a complex interaction of genetic and environmental factors and represents a failure of biliary cholesterol homoeostasis in which the physical-chemical balance of cholesterol solubility in bile is disturbed. DESIGN The primary pathophysiologic event is persistent hepatic hypersecretion of biliary cholesterol, which has both hepatic and small intestinal components. The majority of the environmental factors are… CONTINUE READING