Prevention of chemotherapy-induced menopause by temporary ovarian suppression with goserelin in young, early breast cancer patients.

@article{Mastro2006PreventionOC,
  title={Prevention of chemotherapy-induced menopause by temporary ovarian suppression with goserelin in young, early breast cancer patients.},
  author={Lucia Del Mastro and Tiziana Catzeddu and Luca Boni and Christopher Bell and Mario Roberto Sertoli and Claudia Bighin and Matteo Clavarezza and David Testa and Marco Venturini},
  journal={Annals of oncology : official journal of the European Society for Medical Oncology},
  year={2006},
  volume={17 1},
  pages={74-8}
}
BACKGROUND Standard methods to prevent chemotherapy-induced early menopause in young, breast cancer patients are unavailable to date. Preclinical data has suggested that luteinising hormone-releasing hormone (LH-RH) analogs given during treatment can decrease the gonado-toxicity induced by chemotherapy. This phase II study aimed to assess the activity of such a method in young, breast cancer patients undergoing adjuvant chemotherapy. PATIENTS AND METHODS Premenopausal patients received the LH… CONTINUE READING