Prevention of cerebral vasospasm by calcitonin gene-related peptide slow-release tablet after subarachnoid hemorrhage in monkeys.

@article{Inoue1996PreventionOC,
  title={Prevention of cerebral vasospasm by calcitonin gene-related peptide slow-release tablet after subarachnoid hemorrhage in monkeys.},
  author={Tomoyuki Inoue and Hiroaki Shimizu and T. Kaminuma and Masaharu Tajima and Kounosuke Watabe and Tetsuyuki Yoshimoto},
  journal={Neurosurgery},
  year={1996},
  volume={39 5},
  pages={984-90}
}
OBJECTIVE The goal of this work was to investigate the efficacy of a calcitonin gene-related peptide (CGRP) slow-release tablet (CGRP tablet) for the prevention of cerebral vasospasm after subarachnoid hemorrhage (SAH). METHODS Experimental SAH was produced in 10 cynomolgus monkeys by placing a clot around the internal carotid artery bifurcation (Day 0). In five animals, CGRP tablets (1200 micrograms of CGRP) were then placed in the cerebrospinal fluid space (CGRP group). In two animals… CONTINUE READING