Prevention of cell swelling with low chloride St. Thomas' Hospital solution improves postischemic myocardial recovery.


OBJECTIVE In isolated myocytes cardioplegia-induced cell swelling can be prevented by lowering the KCl product by replacing Cl- with an impermeant ion. This study tested the hypothesis that Cl- substitution in St. Thomas' Hospital cardioplegic solution would result in superior myocardial protection in the intact, blood-perfused heart. METHODS Using a… (More)