Prevention of cell death by the zinc ion chelating agent TPEN in cultured PC12 cells exposed to Oxygen-Glucose Deprivation (OGD).

@article{Liu2015PreventionOC,
  title={Prevention of cell death by the zinc ion chelating agent TPEN in cultured PC12 cells exposed to Oxygen-Glucose Deprivation (OGD).},
  author={Zhao Liu and Yue-yang Huang and Yu-xiang Wang and Hong-gang Wang and Fei Deng and Bin Heng and Lai-hua Xie and Yan-qiang Liu},
  journal={Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements},
  year={2015},
  volume={31},
  pages={45-52}
}
To elucidate the role of Zn(2+)-associated glutamate signaling pathway and voltage-dependent outward potassium ion currents in neuronal death induced by hypoxia-ischemia, PC12 cells were exposed to Oxygen-Glucose Deprivation (OGD) solution mimicking the hypoxic-ischemic condition in neuron, and the effect of N,N,N',N'-tetrakis (2-pyridylmethyl) ethylenediamine (TPEN), a specific Zn(2+) chelating agent on OGD-induced neuronal death was assessed in the present study. The cell survival rate… CONTINUE READING