Prevention of cardiac hypertrophy and heart failure by silencing of NF-kappaB.

  title={Prevention of cardiac hypertrophy and heart failure by silencing of NF-kappaB.},
  author={Sudhiranjan Gupta and David Z. Young and Ratan K. Maitra and Anasuya Gupta and Zoran B Popovi{\'c} and Sandro L. Yong and Anjuli Mahajan and Qing Wang and Subha Sen},
  journal={Journal of molecular biology},
  volume={375 3},
Activation of the nuclear factor (NF)-kappaB signaling pathway may be associated with the development of cardiac hypertrophy and its transition to heart failure (HF). The transgenic Myo-Tg mouse develops hypertrophy and HF as a result of overexpression of myotrophin in the heart associated with an elevated level of NF-kappaB activity. Using this mouse model and an NF-kappaB-targeted gene array, we first determined the components of NF-kappaB signaling cascade and the NF-kappaB-linked genes that… CONTINUE READING

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