Prevention of carbon tetrachloride-induced hepatotoxicity in the rat by H. rosasinensis anthocyanin extract administered in ethanol.

@article{Obi1998PreventionOC,
  title={Prevention of carbon tetrachloride-induced hepatotoxicity in the rat by H. rosasinensis anthocyanin extract administered in ethanol.},
  author={Fredrick O. Obi and I A Usenu and J O Osayande},
  journal={Toxicology},
  year={1998},
  volume={131 2-3},
  pages={93-8}
}
The ability of anthocyanin obtained from the petals of H. rosasinensis to prevent carbon tetrachloride-induced acute liver damage in the rat was examined. Treatment of separate groups of rats with 2.5 ml of 1, 5 and 10% anthocyanin extract in 5% aqueous ethanol/kg body weight, 5 days/week for 4 weeks before 0.5 ml/kg carbon tetrachloride (CCL4) resulted in significantly (P < 0.05) less hepatotoxicity than with CCL4 alone, as measured by serum aspartate and alanine aminotransferase activities 18… CONTINUE READING