Prevention of bile reflux-induced acute gastric ulceration in the rat by cholestyramine.

@article{Mersereau1974PreventionOB,
  title={Prevention of bile reflux-induced acute gastric ulceration in the rat by cholestyramine.},
  author={W. A. Mersereau and E. John Hinchey},
  journal={Annals of surgery},
  year={1974},
  volume={179 6},
  pages={883-8}
}
The role of bile salts and refluxed duodenal content in the pathogenesis of acute gastric ulcers in the shocked rat were examined. The addition of cholestyramine to duodenal contents inhibits their ulcerogenic action in the stomach of rats challenged by an acid load, (100 mEq/l Hcl) and subsequently bled to a mean blood pressure of 20 mm Hg. Also, bile duct… CONTINUE READING