Prevention of basement membrane thickening in retinal capillaries by a novel inhibitor of aldose reductase, tolrestat.

@article{Robison1986PreventionOB,
  title={Prevention of basement membrane thickening in retinal capillaries by a novel inhibitor of aldose reductase, tolrestat.},
  author={W. Gerald Robison and Peter F. Kador and Yoshio Akagi and Jin H. Kinoshita and Ricardo Monreal Gonz{\'a}lez and D M Dvornik},
  journal={Diabetes},
  year={1986},
  volume={35 3},
  pages={295-9}
}
A diabetic-like thickening of retinal capillary basement membranes induced in rats fed for 207 consecutive days a diet containing 50% galactose was prevented by the addition to the diet of tolrestat, a potent, structurally novel inhibitor of aldose reductase. Analysis of electron micrographs (X 25,000) of capillaries from the outer plexiform layer of the retina by computer planimetry showed that the basement membranes were approximately twofold thicker in rats fed galactose than in those fed… CONTINUE READING

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