Prevention of autoimmunity and control of recall response to exogenous antigen by Fas death receptor ligand expression on T cells.

@article{Mabrouk2008PreventionOA,
  title={Prevention of autoimmunity and control of recall response to exogenous antigen by Fas death receptor ligand expression on T cells.},
  author={Imed Mabrouk and St{\'e}phanie Buart and Meriem Hasmim and Christelle Michiels and Elizabeth Connault and Paule Opolon and Gilles Chiocchia and Matthieu L{\'e}vi-Strauss and Salem Chouaib and Saoussen Karray},
  journal={Immunity},
  year={2008},
  volume={29 6},
  pages={922-33}
}
Mice with mutations in the gene encoding Fas ligand (FasL) develop lymphoproliferation and systemic autoimmune diseases. However, the cellular subset responsible for the prevention of autoimmunity in FasL-deficient mice remains undetermined. Here, we show that mice with FasL loss on either B or T cells had identical life span as littermates, and both genotypes developed signs of autoimmunity. In addition, we show that T cell-dependent death was vital for the elimination of aberrant T cells and… CONTINUE READING

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References

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Showing 1-10 of 40 references

The Fas death factor.

View 11 Excerpts
Highly Influenced

B lymphocyte-specific, Cre-mediated mutagenesis in mice.

Nucleic acids research • 1997
View 4 Excerpts
Highly Influenced

T-cell-specific deletion of a polypeptide N-acetylgalactosaminyl-transferase gene by site-directed recombination.

Proceedings of the National Academy of Sciences of the United States of America • 1995
View 4 Excerpts
Highly Influenced

FAS is highly expressed in the germinal center but is not required for regulation of the B-cell response to antigen.

Proceedings of the National Academy of Sciences of the United States of America • 1995
View 5 Excerpts
Highly Influenced

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