Prevention of autoimmune disease by induction of tolerance to Toll-like receptor 7

@article{Hayashi2009PreventionOA,
  title={Prevention of autoimmune disease by induction of tolerance to Toll-like receptor 7},
  author={T. Hayashi and C. Gray and Michael Chan and R. Tawatao and L. Ronacher and M. McGargill and S. Datta and D. Carson and M. Corr},
  journal={Proceedings of the National Academy of Sciences},
  year={2009},
  volume={106},
  pages={2764 - 2769}
}
Activation of Toll-like receptors (TLR) contributes to the initiation and maintenance of chronic inflammation in autoimmune diseases, yet repeated exposure to a TLR agonist can induce hyporesponsiveness to subsequent TLR stimulation. Here, we used a synthetic TLR7 agonist, 9-benzyl-8-hydroxy-2-(2-methoxyethoxy) adenine (SM360320, 1V136) to study TLR7 induced attenuation of inflammatory responses and its application to autoimmune diseases. Repeated low dose administration of this TLR7 agonist… Expand
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References

SHOWING 1-10 OF 43 REFERENCES
Macrophage tolerance induced by stimulation with Toll-like receptor 7/8 ligands.
Mast cell-dependent anorexia and hypothermia induced by mucosal activation of Toll-like receptor 7.
  • T. Hayashi, H. Cottam, +7 authors M. Corr
  • Biology, Medicine
  • American journal of physiology. Regulatory, integrative and comparative physiology
  • 2008
Toll-like receptors, inflammation and cancer.
  • M. Tsan
  • Biology, Medicine
  • Seminars in cancer biology
  • 2006
Role for MyD88-Independent, TRIF Pathway in Lipid A/TLR4-Induced Endotoxin Tolerance1
Innate immunity mediated by TLR9 modulates pathogenicity in an animal model of multiple sclerosis.
Interleukin 1 Receptor Dependence of Serum Transferred Arthritis Can be Circumvented by Toll-like Receptor 4 Signaling
The role of toll-like receptors in systemic lupus erythematosus
...
1
2
3
4
5
...