Prevention of atherosclerosis in apolipoprotein E-deficient mice by bone marrow transplantation.

@article{Linton1995PreventionOA,
  title={Prevention of atherosclerosis in apolipoprotein E-deficient mice by bone marrow transplantation.},
  author={Macrae F Linton and J. Ben Atkinson and Sergio Fazio},
  journal={Science},
  year={1995},
  volume={267 5200},
  pages={1034-7}
}
Apolipoprotein E (apoE) deficiency causes severe hyperlipidemia and atherosclerosis in humans and in gene-targeted mice. Although the majority of apoE in plasma is of hepatic origin, apoE is synthesized by a variety of cell types, including macrophages. Because macrophages derive from hematopoietic cells, bone marrow transplantation was used to examine the potential of apoE synthesized by bone marrow-derived cells to correct the hyperlipidemia and atherosclerosis caused by apoE deficiency… CONTINUE READING
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