Prevention of atherosclerosis by interference with the vascular nitric oxide system.

@article{Li2009PreventionOA,
  title={Prevention of atherosclerosis by interference with the vascular nitric oxide system.},
  author={Huige Li and Ulrich Foerstermann},
  journal={Current pharmaceutical design},
  year={2009},
  volume={15 27},
  pages={
          3133-45
        }
}
Nitric oxide (NO) produced by endothelial NO synthase (eNOS) represents an anti-atherosclerotic principle. NO bioavailability is decreased in atherosclerosis due to increased NO inactivation by reactive oxygen species and reduced NO synthesis. Various types of vascular pathophysiology are associated with oxidative stress, with NADPH oxidases as the major source of reactive oxygen species. These inactivate NO. Also, oxidative stress is likely to be the main cause for oxidation of the essential… CONTINUE READING
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