Prevention of apoptotic but not necrotic cell death following neuronal injury by neurotrophins signaling through the tyrosine kinase receptor.

@article{Kim2004PreventionOA,
  title={Prevention of apoptotic but not necrotic cell death following neuronal injury by neurotrophins signaling through the tyrosine kinase receptor.},
  author={Dong Hyun Kim and Xiurong Zhao and Christina H. Tu and Patrizia Casaccia-Bonnefil and Moses V Chao},
  journal={Journal of neurosurgery},
  year={2004},
  volume={100 1},
  pages={79-87}
}
OBJECT Neurotrophins prevent the death of neurons during embryonal development and have potential as therapeutic agents. During development, neuronal death occurs only by apoptosis and not by necrosis. Following injury, however, neurons can die by both processes. Data from prior studies have not clearly indicated whether neurotrophins can decrease apoptosis compared with necrosis. The goal of this study was to determine the effect of neurotrophin treatment on each of these processes following… CONTINUE READING

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