Prevention of antiinflammatory drug-induced gastric lesions in rats by Abbott-29590

@article{Dodge1974PreventionOA,
  title={Prevention of antiinflammatory drug-induced gastric lesions in rats by Abbott-29590},
  author={Dr. Patrick W. Dodge and D A David A Brodie and Patrick R. Young and Ruth A. Krause and PhD Sait Tekeli DVM},
  journal={The American Journal of Digestive Diseases},
  year={1974},
  volume={19},
  pages={449-457}
}
Abbott-29590, an antiinflammatory compound with antipyretic and analgesic activity in test animals, did not produce any gastric lesions in the rat after oral doses up to 256 mg/kg. In contrast, gastric lesions were produced by oral doses of aspirin, indomethacin, and phenylbutazone; the ED95 values were 88, 13, and 260 mg/kg, respectively. Pretreatment with… CONTINUE READING