Prevention of angiotensin II-induced cardiac remodeling by angiotensin-(1-7).

  title={Prevention of angiotensin II-induced cardiac remodeling by angiotensin-(1-7).},
  author={Justin L Grobe and Adam P. Mecca and Melissa Lingis and Vinayak Shenoy and Tonya A Bolton and J. Miguel Machado and Robert C Speth and Mohan K. Raizada and Michael J. Katovich},
  journal={American journal of physiology. Heart and circulatory physiology},
  volume={292 2},
Cardiac remodeling, which typically results from chronic hypertension or following an acute myocardial infarction, is a major risk factor for the development of heart failure and, ultimately, death. The renin-angiotensin system (RAS) has previously been established to play an important role in the progression of cardiac remodeling, and inhibition of a hyperactive RAS provides protection from cardiac remodeling and subsequent heart failure. Our previous studies have demonstrated that… CONTINUE READING
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