Prevention of anaphylaxis with ant venom immunotherapy

  title={Prevention of anaphylaxis with ant venom immunotherapy},
  author={Simon G. A. Brown and Robert J. Heddle},
  journal={Current Opinion in Allergy and Clinical Immunology},
  • S. Brown, R. Heddle
  • Published 1 December 2003
  • Medicine, Biology
  • Current Opinion in Allergy and Clinical Immunology
Purpose of reviewWorldwide, eight genera of ants have been associated with sting allergy. Until recently only whole ant body extracts have been used for immunotherapy. The purpose of this review is to examine recent advances in the understanding of ant venom allergy and treatment using venom immunotherapy. Recent findingsPublic health problems due to severe ant sting anaphylaxis are not confined to the imported fire ant of North America. Pachycondyla sennaarensis (samsum ant), Pachycondyla… 

Global View on Ant Venom Allergy: from Allergenic Components to Clinical Management

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Anaphylaxis to Insect Venom Allergens: Role of Molecular Diagnostics

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Diagnosis of Hymenoptera venom allergy

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Components and Mechanisms in Diagnosis and Therapy of Hymenoptera Venom Allergy

Anaphylaxis due to Hymenoptera stings is one of the most severe clinical outcomes of IgE-mediated hypersensitivity reactions. Although allergic reactions to Hymenoptera stings are often considered as

Fatalities following allergen immunotherapy

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Stinging insect allergy: state of the art 2015.

Ant sting-induced whole-body pustules in an inebriated male: A case report

A 70-year-old man was bitten by a large number of ants when he was in a drunken stupor and was hospitalized at a local hospital, where he was diagnosed with an ant venom allergy.

Black ant stings caused by Pachycondyla sennaarensis: a significant health hazard

Cases of allergic reactions following insect bites or stings that presented to the emergency department and that were caused by the black samsum ant are presented, indicating that ant stings are a significant public health hazard in Saudi Arabia.

Ant venoms

  • D. Hoffman
  • Chemistry
    Current opinion in allergy and clinical immunology
  • 2010
Ants share some common proteins in venoms, but each group appears to have a number of possibly unique components and further proteomic studies should expand and clarify knowledge of these fascinating animals.



Anaphylaxis caused by the new ant, Pachycondyla chinensis: demonstration of specific IgE and IgE-binding components.

IgE-mediated reactions contributed to the development of P chinensis -induced anaphylaxis and further studies will be needed to clarify the role of sIgG4 and to identify allergenic relationships with major bee and wasp allergens.

Allergens in Hymenoptera venoms. XXIII. Venom content of imported fire ant whole body extracts.

The amount of imported fire ant venom in a potent whole body extract appears to be sufficient to provide possible protection for patients receiving it as immunotherapy, although this can only be verified by controlled clinical trials with intentional sting challenges.

Venom immunotherapy improves health-related quality of life in patients allergic to yellow jacket venom.

VIT results in a clinically important improvement in HRQL in patients allergic to yellow jacket venom in all subgroups studied, and this improvement was statistically significant.

Prevalence, severity, and natural history of jack jumper ant venom allergy in Tasmania.

M pilosula sting exposure in Tasmania is excessive compared with that found in mainland Australia, and there is a high systemic reaction risk in allergic people on re-sting.

Safety and efficacy of an imported fire ant rush immunotherapy protocol with and without prophylactic treatment.

RIT with IFA WBE for IFA hypersensitivity is both safe and efficacious; the rate of mild systemic reactions is low;Premedication is not necessary as prophylactic pretreatment with antihistamines and steroids did not reduce the systemic reaction rate associated with RIT.