Prevention of ammonia toxicity byl-carnitine: metabolic changes in brain

@article{OConnor1984PreventionOA,
  title={Prevention of ammonia toxicity byl-carnitine: metabolic changes in brain},
  author={Jos{\'e}-Enrique O'Connor and Mercedes Costell and Santiago Grisol{\^i}a},
  journal={Neurochemical Research},
  year={1984},
  volume={9},
  pages={563-570}
}
l-Carnitine when injected in mice 30 min before an LD100 of ammonium acetate (12 mmol/kg body weight, intraperitoneal) reduced mortality (100% survival with 16 mmoll-carnitine/kg) and prevented the appearance of symptoms of ammonia toxicity. Brain ammonia decreased in the animals givenl-carnitine. Ammonia decreased the levels of glutamate in brain; they were partially restored byl-carnitine, which also reduced the increase in brain glutamine in animals given only ammonia. The redox state of the… CONTINUE READING
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