Prevention of acute liver failure in rats with reversibly immortalized human hepatocytes.

@article{Kobayashi2000PreventionOA,
  title={Prevention of acute liver failure in rats with reversibly immortalized human hepatocytes.},
  author={Nobumichi Kobayashi and Toshihisa Fujiwara and Karen A. Westerman and Yoshiaki Inoue and Masakiyo Sakaguchi and Hirofumi Noguchi and Masahiro Miyazaki and Jin H Cai and Noriaki Tanaka and Ira J. Fox and Philippe Leboulch},
  journal={Science},
  year={2000},
  volume={287 5456},
  pages={1258-62}
}
Because of a critical shortage in suitable organs, many patients with terminal liver disease die each year before liver transplantation can be performed. Transplantation of isolated hepatocytes has been proposed for the temporary metabolic support of patients awaiting liver transplantation or spontaneous reversion of their liver disease. A major limitation of this form of therapy is the present inability to isolate an adequate number of transplantable hepatocytes. A highly differentiated cell… CONTINUE READING

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