Prevention of activated neutrophil adhesion to endothelium by soluble adhesion protein GMP140.

@article{Gamble1990PreventionOA,
  title={Prevention of activated neutrophil adhesion to endothelium by soluble adhesion protein GMP140.},
  author={Jennifer R. Gamble and Michael P. Skinner and Michael C. Berndt and Mathew A. Vadas},
  journal={Science},
  year={1990},
  volume={249 4967},
  pages={414-7}
}
Neutrophils and monocytes, but not lymphocytes, adhered strongly to plastic surfaces coated with GMP140, a protein of endothelial cells and platelets. This adhesion of neutrophils was mediated by GMP140 and not by the CD18 integrin complex. By contrast, GMP140 in solution inhibited the CD18-dependent adhesion of tumor necrosis factor-alpha-activated neutrophils to plastic surfaces and resting endothelium, but not of resting neutrophils to tumor necrosis factor-alpha-activated endothelium. Thus… CONTINUE READING

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