Prevention of Vocal Fold Scarring by Topical Injection of Hepatocyte Growth Factor in a Rabbit Model

@article{Hirano2004PreventionOV,
  title={Prevention of Vocal Fold Scarring by Topical Injection of Hepatocyte Growth Factor in a Rabbit Model},
  author={Shigeru Hirano and Diane Bless and Bernard Rousseau and Nathan V. Welham and Douglas W. Montequin and Roger W. Chan and Charles N. Ford},
  journal={The Laryngoscope},
  year={2004},
  volume={114}
}
Objectives/Hypothesis Vocal fold scarring disrupts the layer structure of the vocal fold lamina propria that is essential for optimal mucosal vibration. Prevention of vocal fold scarring remains challenging. Hepatocyte growth factor (HGF) has strong antifibrotic activity. The authors' previous studies have found that HGF stimulates hyaluronic acid production and suppresses collagen production from vocal fold fibroblasts, suggesting that HGF has therapeutic potential in prevention of vocal fold… 
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The aim of this study was to clarify the effectiveness of basic fibroblast growth factor (bFGF) for prevention of postsurgical vocal fold scarring.
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TLDR
The effect of HGF‐DDS on chronic vocal fold scarring using a canine model is investigated to investigate the therapeutic potential of hepatocyte growth factor in the management of acute phase vocal fold Scarring.
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TLDR
A porcine model of vocal fold scarring was used to test effects of decorin and primed vocal fold fibroblasts in vitro using a cell migration assay and immunoblotting.
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TLDR
The effect of 5 amino acid‐deleted type HGF in comparison with full‐length HGF for the treatment of vocal fold scars using a canine model is investigated.
Drug Delivery System of Hepatocyte Growth Factor for the Treatment of Vocal Fold Scarring in a Canine Model
TLDR
The present findings suggest that the novel HGF DDS may provide favorable effects in restoring the vibratory properties of scarred vocal folds.
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TLDR
The results suggest that vitamin A can prevent scar formation in the vocal fold after surgery, and topically applied vitamin A on healing after vocal fold trauma is suggested.
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TLDR
Significant increase of hyaluronic acid by local bFGF injection was thought to contribute to the therapeutic effects on chronic vocal fold scarring.
The Efficacy of Fibroblast Growth Factor for the Treatment of Chronic Vocal Fold Scarring: From Animal Model to Clinical Application
TLDR
Based on the animal model and the prospective clinical trial, vocal fold injections of FGF in patients with mild chronic vocal fold scarring can significantly improve voice quality for as long as 1 year and without side effects.
Current treatment of vocal fold scarring.
  • S. Hirano
  • Medicine
    Current opinion in otolaryngology & head and neck surgery
  • 2005
TLDR
Various new therapeutic strategies have been developed in animal models using tissue engineering and regenerative medicine for vocal fold scarring, but no clinical trials have been performed, and more studies are necessary to establish the optimum modality.
Primed fibroblasts and exogenous decorin: Potential treatments for subacute vocal fold scar
TLDR
HGF and decorin together may decrease collagen production by skin and vocal fold fibroblasts, and fibroblast transplantation into scarred vocal folds has equivocal benefit.
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TLDR
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TLDR
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