Prevention of Vitamin K Deficiency Bleeding in Newborn Infants: A Position Paper by the ESPGHAN Committee on Nutrition

@article{Mihatsch2016PreventionOV,
  title={Prevention of Vitamin K Deficiency Bleeding in Newborn Infants: A Position Paper by the ESPGHAN Committee on Nutrition},
  author={Walter Mihatsch and Christian P. Braegger and Jiř{\'i} Bronsk{\'y} and Cristina Campoy and Magnus Domell{\"o}f and Mary S Fewtrell and Nata{\vs}a Fidler Mis and Iva Hojsak and Jessie Hulst and Flavia Indrio and Alexandre Lapillonne and Christian M⊘lgaard and Nicholas D. Embleton and Johannes B. van Goudoever},
  journal={Journal of Pediatric Gastroenterology and Nutrition},
  year={2016},
  volume={63},
  pages={123–129}
}
ABSTRACT Vitamin K deficiency bleeding (VKDB) due to physiologically low vitamin K plasma concentrations is a serious risk for newborn and young infants and can be largely prevented by adequate vitamin K supplementation. The aim of this position paper is to define the condition, describe the prevalence, discuss current prophylaxis practices and outcomes, and to provide recommendations for the prevention of VKDB in healthy term newborns and infants. All newborn infants should receive vitamin K… Expand
Vitamin K prophylaxis in newborns
We looked at existing recommendations and supporting evidence on the effectiveness of vitamin K given after birth in preventing the haemorrhagic disease of the newborn (HDN). We conducted aExpand
Educating Parents on Vitamin K Prophylaxis for Newborns.
TLDR
The risks of vitamin K deficiency bleeding in newborns are high, and if a dose is missed, the risk of VKDB may more than double. Expand
Increasing the dose of oral vitamin K prophylaxis and its effect on bleeding risk
TLDR
A sixfold increase in oral vitamin K prophylaxis was associated with a surprisingly modest reduction in the incidence of intracranial VKDB, indicating that factors other than the dose need addressing to improve efficacy. Expand
Vitamin K deficiency: a case report and review of current guidelines
TLDR
It is necessary to revise the current guidelines in order to standardize timing and dosage in different clinical conditions for vitamin K deficiency bleeding, as this case developed a VKDB. Expand
Vitamin K deficiency bleeding in an apparently healthy newborn infant: the compelling need for evidence-based recommendation
TLDR
The described infant did not show any pathological elements in pregnancy history or perinatal life which suggest a possible increased risk of bleeding and the needing of a particular approach in the administration of vitamin K1, but at the end of the first week of life presented an intracranial bleeding with neurological symptoms that required treatment for vitamin K deficiency. Expand
The challenge to define the optimal prophylactic regimen for vitamin K deficiency bleeding in infants
TLDR
The introduction of combined proPHylactic strategy with prolonged oral prophylaxes after the intramuscular dose at birth has showed a decrease of the late severe VKDB incidence, Nevertheless, there is still lack of consensus about the administration scheme after the first dose atBirth. Expand
Late vitamin K deficiency bleeding in infants: Five-year prospective study.
TLDR
Secondary late VKDB is more common than the primary subtypes, and lateVKDB is still a serious disease in developing countries, including Iraq, when vitamin K prophylaxis isn't routinely used at birth. Expand
Vitamin K Is Necessary for Newborns
TLDR
Vitamin K was first discovered in 1929 by Henrik Dam, who observed hemorrhages in chicks fed fat-free diets, and Edward Doisy identified the structure and forms in the 1940s, and both men received the Nobel Prize for their collective work on vitamin K in 1943. Expand
Appropriate and inappropriate vitamin supplementation in children
TLDR
The present article is to analyse the state of the art and consider new perspectives on the role of vitamin supplements in children, especially in emerging conditions of paediatric age such as type 2 diabetes and the metabolic syndrome. Expand
Mineral and vitamin intake of infants and young children: the Nutri-Bébé 2013 survey
TLDR
This survey highlights excessive sodium intake as well as a shortfall of iron, vitamin D, and vitamin E intakes in toddlers, in comparison with the European Food Safety Authority Adequate Intake according to age. Expand
...
1
2
3
4
...

References

SHOWING 1-10 OF 118 REFERENCES
Late Vitamin K Deficiency Bleeding in Infants Whose Parents Declined Vitamin K Prophylaxis — Tennessee, 2013
TLDR
Administration of intramuscular vitamin K at birth to prevent all forms of vitamin K deficiency bleeding has been standard practice since first recommended by the American Academy of Pediatrics in 1961. Expand
Prevention of Vitamin K Deficiency Bleeding in Breastfed Infants: Lessons From the Dutch and Danish Biliary Atresia Registries
TLDR
A daily dose of 25 μg of vitamin K fails to prevent bleedings in apparently healthy infants with unrecognized cholestasis because of biliary atresia, and one milligram of weekly oral prophylaxis offers significantly higher protection to these infants and is of similar efficacy as 2 mg of intramuscular proPHylaxis at birth. Expand
Rise in late onset vitamin K deficiency bleeding in young infants because of omission or refusal of prophylaxis at birth.
BACKGROUND Newborns are at risk for vitamin K deficiency and subsequent bleeding unless supplemented at birth. Vitamin K deficiency bleeding is an acquired coagulopathy in newborn infants because ofExpand
Incidence of late vitamin K deficiency bleeding in newborns in the Netherlands in 2005: evaluation of the current guideline
TLDR
Doubling the daily dose of vitamin K1 to 50 μg, as is comparable to formula-feeding, may possibly prevent VKDB in this group of breastfed infants; further research is needed to prove this hypothesis. Expand
[New Dutch practice guideline for administration of vitamin K to full-term newborns].
TLDR
After evaluation of current literature and advice from The Health Council of the Netherlands, vitamin K dosage was adapted for all breastfed infants from day 8 to 3 months (12th week of life) following birth: the daily dose was raised from 25 µg to 150 µg per day. Expand
Prevention of vitamin K deficiency bleeding: efficacy of different multiple oral dose schedules of vitamin K
TLDR
The Australian data confirm that three oral doses of 1 mg vitamin K are less effective than i.m. vitamin K prophylaxis, and the effectiveness of the “mixed-micellar” preparation of vitamin K1 needs further study. Expand
Vitamin K deficiency bleeding (VKDB) in early infancy.
TLDR
Late VKDB is largely preventable with parenteral vitamin K providing the best protection and most multi-dose oral regimens provide protection for all except a small reservoir of infants with undetected hepatobiliary disease. Expand
Evaluation of a daily dose of 25 micrograms vitamin K1 to prevent vitamin K deficiency in breast-fed infants.
TLDR
Daily supplementation of 25 micrograms vitamin K1 can be recommended for breast-fed infants to prevent vitamin K deficiency beyond the neonatal period. Expand
Evaluation of a Daily Dose of 25 μg Vitamin K1 to Prevent Vitamin K Deficiency in Breast‐Fed Infants
TLDR
Daily supplementation of 25 μg vitamin K1 can be recommended for breast-fed infants to prevent vitamin K deficiency beyond the neonatal period. Expand
Controversies Concerning Vitamin K and the Newborn
TLDR
Late HDN, a syndrome defined as unexpected bleeding due to severe vitamin K deficiency in infants aged 2 to 12 weeks, occurs primarily in exclusively breast-fed infants who have received no or inadequate neonatal vitamin K prophylaxis. Expand
...
1
2
3
4
5
...