Prevention of TGFβ induction attenuates angII-stimulated vascular biglycan and atherosclerosis in Ldlr-/- mice.

@article{Tang2013PreventionOT,
  title={Prevention of TGFβ induction attenuates angII-stimulated vascular biglycan and atherosclerosis in Ldlr-/- mice.},
  author={Tao Tang and Patricia G Wilson and Joel C Thompson and C A Nelson and Meghan H Yoder and Lisa R. Tannock},
  journal={Journal of lipid research},
  year={2013},
  volume={54 8},
  pages={2255-64}
}
Angiotensin II (angII) accelerates atherosclerosis, but the mechanisms are not fully understood. The aim of this study was to determine whether TGFβ is required for angII-induced atherosclerosis. Ldlr-null mice fed a normal chow diet were infused with angII or saline for 28 days. A single injection of TGFβ neutralizing antibody 1D11 (2 mg/kg) prevented angII-induction of TGFβ1 levels, and strikingly attenuated angII-induced accumulation of aortic biglycan content. To study atherosclerosis, mice… CONTINUE READING