Prevention of Surgical Site Infections: Decontamination With Mupirocin Based on Preoperative Screening for Staphylococcus aureus Carriers or Universal Decontamination?

@article{Hetem2016PreventionOS,
  title={Prevention of Surgical Site Infections: Decontamination With Mupirocin Based on Preoperative Screening for Staphylococcus aureus Carriers or Universal Decontamination?},
  author={David J. Hetem and Martin C. J. Bootsma and Marc J. M. Bonten},
  journal={Clinical infectious diseases : an official publication of the Infectious Diseases Society of America},
  year={2016},
  volume={62 5},
  pages={
          631-6
        }
}
Perioperative decolonization of Staphylococcus aureus nasal carriers with mupirocin together with chlorhexidine body washing reduces the incidence of S. aureus surgical site infection. A targeted strategy, applied in S. aureus carriers only, is costly, and implementation may reduce effectiveness. Universal decolonization is more cost-effective but increases exposure of noncarriers to mupirocin and the risk of resistance to mupirocin in staphylococci. High-level mupirocin resistance in S. aureus… CONTINUE READING
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