Prevention of Reg I-induced β-cell apoptosis by IL-6/dexamethasone through activation of HGF gene regulation.

@article{Nakagawa2013PreventionOR,
  title={Prevention of Reg I-induced β-cell apoptosis by IL-6/dexamethasone through activation of HGF gene regulation.},
  author={Kei Nakagawa and Shin Takasawa and Koji Nata and Akiyo Yamauchi and Asako Itaya-Hironaka and Hiroyo Ota and Kiyomi Yoshimoto and Sumiyo Sakuramoto-Tsuchida and Tomoko Miyaoka and Maiko Takeda and Michiaki Unno and Hiroshi Okamoto},
  journal={Biochimica et biophysica acta},
  year={2013},
  volume={1833 12},
  pages={2988-2995}
}
Reg (regenerating gene) product, Reg protein, is induced in pancreatic β-cells and acts as autocrine/paracrine growth factor for regeneration via the cell surface Reg receptor. However, high concentrations of Reg I protein induced β-cell apoptosis. In the present study, we found that hepatocyte growth factor (HGF) attenuated the β-cell apoptosis induced by the high concentrations of Reg I protein and that the combined stimulation of interleukin-6 (IL-6) and dexamethasone (Dx) induced the… CONTINUE READING
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