Prevention of Pyelonephritis by Water Diuresis: Evidence for the Role of Medullary Hypertonicity in Promoting Renal Infection.


The medulla of the kidney is much more susceptible to infection than the cortex (1-5). The unique vulnerability of the renal medulla has been ascribed in the past to its anatomical location (6), to its relatively poor circulation (7), and to its chemical composition, in particular to its content of ammonia and ammonia-producing enzymes that inhibit the… (More)


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