Prevention of Pulmonary Complications of Pneumoperitoneum in Rats

  title={Prevention of Pulmonary Complications of Pneumoperitoneum in Rats},
  author={Sami Karapolat and Suat Gezer and Umran Yildirim and Talha Dumlu and Banu Karapolat and Ismet Ozaydin and Mehmet Yasar and Abdulkadir Iskender and Hayati Kandiş and Ayhan Saritas},
  booktitle={Journal of cardiothoracic surgery},
BACKGROUND Carbon dioxide (CO2) pneumoperitoneum facilitates the visualization of abdominal organs during laparoscopic surgery. However, the associated increase in intra-abdominal pressure causes oxidative stress, which contributes to tissue injury. OBJECTIVE We investigated the ability of the antioxidant and anti-inflammatory drug Erdosteine to prevent CO2 pneumoperitoneum-induced oxidative stress and inflammatory reactions in a rat model. METHODS Fourteen female adult Wistar albino rats… CONTINUE READING