Prevention of Psychological Effects of d-Lysergic Acid Diethylamide (LSD 25) by its 2-Brom Derivative (BOL 148)

@article{Ginzel1956PreventionOP,
  title={Prevention of Psychological Effects of d-Lysergic Acid Diethylamide (LSD 25) by its 2-Brom Derivative (BOL 148)},
  author={K. H. Ginzel and W. Mayer-gross},
  journal={Nature},
  year={1956},
  volume={178},
  pages={210-210}
}
IN view of the blocking effect often exerted by the close chemical analogue of a pharmacologically specific agent, we tried to determine whether the psychological symptoms induced by D-lysergic acid diethylamide (LSD 25) could be influenced by one of its psychologically inactive derivatives. The 2-brom derivative of LSD 25 (BOL 148) exerts no psychological effects1. 
Cross tolerance between d-2-brom-lysergic acid diethylamide (BOL-148) and the d-diethylamide of lysergic acid (LSD-25)
TLDR
Simultaneous administration of 2 to 4 mg of d-2-Brom lysergic acid diethylamide (BOL-148) did not reduce the intensity of the reaction caused by 0.5 to 1.5mcg/kg of LSD-25, and pre-treatment resulted in statistically significant attenuation of all aspects of the LSD reaction that were measured.
The preservation of substance P by lysergic acid diethylamide.
  • W. Krivoy
  • Chemistry, Medicine
    British journal of pharmacology and chemotherapy
  • 1957
TLDR
The inhibition of the destruction of substance P by LSD could be antagonized by 2 bromo-LSD, and the response of guinea-pig ileum to substance P but not to histamine was potentiated.
Studies on lysergic acid diethylamide (LSD-25). III. Attempts to attenuate the LSD-reaction in man by pretreatment with neurohumoral blocking agents.
TLDR
A hypothesis which ascribes the LSD psychosis to competition between LSD and serotonin for receptor sites on or in neurons, which might be termed the serotonin-deficiency theory, is based in part on the following evidence: Serotonin is found in brain, 6.
Potentiation of substance P by lysergic acid diethvlamide in vivo.
  • W. Krivoy
  • Chemistry, Medicine
    British journal of pharmacology and chemotherapy
  • 1961
TLDR
In doses of 10 mug/kg or more, lysergic acid diethylamide enhanced the fourth potential (DR IV) of the dorsal root potential complex in the cat and revealed an enhancement of the potential by substance P, which by itself had no effect.
The effect of lysergic acid diethylamide, 5-hydroxytryptamine, and related compounds on the liver fluke, Fasciola hepatica.
  • T. Mansour
  • Biology, Medicine
    British journal of pharmacology and chemotherapy
  • 1957
TLDR
Evidence which suggests the presence of tryptamine receptors in the trematode is discussed, and other analogues such as yohimbine, harmine, and dopamine depressed rhythmical movement and antagonized the stimulant action of 5-hydroxytryptamine and lysergic acid diethylamide.
LSD-like delirium following ingestion of a small amount of its brom analog (BOL-148).
Excerpt In 1943 Hoffmann1detected in himself strange mental effects from a compound that he and Stoll2had prepared in 1938 and reported in 1943 as an oxytocic agent similar to ergonovine. This obse...
D‐Lysergic acid diethylamide (LSD): A review of its present status
  • A. Hoffer
  • Psychology, Medicine
    Clinical pharmacology and therapeutics
  • 1965
TLDR
This is a review of an important but controversial subject, written by one of the important figures involved in the controversy, and thought important to bring details of the subject to the attention of a large readership.
Some Compounds With Hallucinogenic Activity
Although “delusional insanity” has been reported among the manifestations of convulsive ergotism (Barger, 1931), none of the naturally occurring ergot alkaloids have typical hallucinogenic
Role of Serotoninergic Neurons and 5-HT Receptors in the Action of Hallucinogens
TLDR
Brain serotonin receptors and serotoninergic pathways have received increasing attention as targets for a wide variety of therapeutic agents, but the so-called hallucinogenic drugs, which presently lack demonstrated therapeutic utility, still remain pharmacological curiosities.
Pharmacology and Classification of LSD-like Hallucinogens
Hallucinogens of the LSD-type have been used since antiquity (Schultes, 1969, 1970a, b). Peyote and mushrooms containing psilocin (Heim and Wasson, 1958; Wasson, 1959) were used by Indians of the
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References

Role of 5-Hydroxytryptamine in Mental Diseases and its Antagonism to Lysergic Acid Derivatives
TLDR
The hypothesis is that certain of the actions of 5-hydroxytryptamine are antagonized by lysergic acid diethylamide, a drug which on oral application and in doses of only 0.5–1.0 µgm./kgm produces pronounced psychic disturbances in normal human beings.