Prevention of Proliferative Vitreoretinopathy by Suppression of Phosphatidylinositol 5-Phosphate 4-Kinases

@inproceedings{Ma2016PreventionOP,
  title={Prevention of Proliferative Vitreoretinopathy by Suppression of Phosphatidylinositol 5-Phosphate 4-Kinases},
  author={Gaoen Ma and Yajian Duan and Xionggao Huang and Cynthia Xin-ya Qian and Yewlin E. Chee and Shizuo Mukai and Jing Zhao Cui and Arif F Samad and Joanne Aiko Matsubara and Andrius Kazlauskas and Patricia A D'Amore and Shuyan Gu and Hetian Lei},
  booktitle={Investigative ophthalmology & visual science},
  year={2016}
}
PURPOSE Previous studies have shown that vitreous stimulates degradation of the tumor suppressor protein p53 and that knockdown of phosphatidylinositol 5-phosphate 4-kinases (PI5P4Kα and -β) abrogates proliferation of p53-deficient cells. The purpose of this study was to determine whether vitreous stimulated expression of PI5P4Kα and -β and whether… CONTINUE READING