Prevention of Nausea and Vomiting with Tandospirone in Adults After Tympanoplasty

  title={Prevention of Nausea and Vomiting with Tandospirone in Adults After Tympanoplasty},
  author={Tsutomu Oshima and Yoshiko Kasuya and Yasuhisa Okumura and Etsuji Terazawa and Shuji Dohi},
  journal={Anesthesia \& Analgesia},
We have hypothesized that the 5-hydroxytrypta-mine-1A receptor agonist tandospirone reduces postoperative nausea and vomiting (PONV). In a double-blinded, randomized design, 3 groups of 30 patients each received 1 of the following oral medications 90 min before arrival in the operating room, together with famotidine 20 mg: 1) placebo (P group), 2) tandospirone 10 mg (T10 group), or 3) tandospirone 30 mg (T30 group). Standard anesthetic regimens and techniques were applied for all patients. All… 

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Palonosetron could provide effective prophylactic antiemetic control to prevent postoperative nausea and vomiting after middle ear surgery under general anesthesia.

Intravenous buspirone for the prevention of postoperative nausea and vomiting

It was unable to show that intravenous single-dose buspirone, at the tested dose-range, was effective at preventing PONV in surgical adult patients, and the present study emphasises the difficulty in extrapolating from animal models of emesis to clinical efficacy in PonV.

Oral tandospirone and clonidine provide similar relief of preoperative anxiety

Oral tandospirone was equivalent to oral clonidine in terms of reduction in preoperative anxiety and the STAl-state decreased in the T group while exhibiting no significant changes in the C group.

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Palonosetron was found an effective and better antiemetic than ramosetrons in patients undergoing middle ear surgeries and Severity of nausea, retching and vomiting was also found to be significantly high in ramOSetron group as compared to the patients received palonosettron.

Drugs for preventing postoperative nausea and vomiting in adults after general anaesthesia: a network meta-analysis.

BACKGROUND Postoperative nausea and vomiting (PONV) is a common adverse effect of anaesthesia and surgery. Up to 80% of patients may be affected. These outcomes are a major cause of patient

Retraction Notice: Clinical Strategies for Preventing Postoperative Nausea and Vomitting after Middle Ear Surgery in Adult Patients

This article is being retracted as a result of failure of Dr. Fijii's institution as well as of himself to rationalize the legitimacy of the study and/or its data as stipulated in request by the Editors-in-Chief of the journals extended on April 9, 2012.

WITHDRAWN: Drugs for preventing postoperative nausea and vomiting.

Postoperative nausea or vomiting is reported to affect, at most, 80 out of 100 people after surgery, and between one to five patients out of every 100 people may experience a mild side effect, such as sedation or headache, when given an antiemetic drug.

Correlation between emotion and pain in patients with dental phobia: a clinical study

It is demonstrated that anxiety amplifies pain in patients with dental phobia and the suppression of patient anxiety could also lead to the reduction of pain.

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The efficacy of ondansetron 4 mg and 8 mg was compared with placebo in the reduction of postoperative nausea, retching and vomiting (PONV) after middle ear surgery during general anaesthesia, in 75

Prevention of nausea and vomiting with transdermal hyoscine in adults after middle ear surgery during general anaesthesia.

The results suggest that transdermal hyoscine is a useful prophylaxis against nausea and vomiting after middle ear surgery.

The Anxiolytic Effects of the 5-Hydroxytryptamine-1A Agonist Tandospirone Before Otolaryngologic Surgery

Tandospirone, 10 and 30 mg, safely reduced preoperative anxiety to a similar extent as oral diazepam 10 mg in patients undergoing elective otolaryngologic surgery.

Granisetron in the prevention of nausea and vomiting after middle-ear surgery: a dose-ranging study.

Granisetron 40 micrograms kg-1 appears to be the minimum effective dose for preventing PONV in women undergoing middle-ear surgery.

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It is concluded that transdermal scopolamine is effective in reducing, but not eliminating, postoperative nausea and vertigo after discharge in outpatient ear surgery.

Delayed Side Effects of Droperidol After Ambulatory General Anesthesia

The incidence of postoperative effects of droperidol, in the hospital and at home the following night, after general anesthesia for minor outpatient procedures was evaluated and it is suggested that the routine use of droeridol in all outpatients receiving general anesthesia may not be appropriate.

Postoperative Nausea and Vomiting: Its Etiology, Treatment, and Prevention

Patients at high risk for postoperative emesis should receive special considerations with respect to the prophylactic use of antiemetic drugs, as suggested in a recent editorial.

8-OH-DPAT suppresses vomiting in the cat elicited by motion, cisplatin or xylazine

Blockade of 5-Hydroxytryptamine3 receptors prevents cisplatin-induced but not motion- or xylazine-induced emesis in the cat

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