Prevention of NSAID-Induced Ulcers.

  title={Prevention of NSAID-Induced Ulcers.},
  author={James M. Scheiman},
  journal={Current treatment options in gastroenterology},
  volume={11 2},
Cyclooxygenase-2 (COX-2) selective inhibitors were developed as gastrointestinal (GI) safer alternatives to nonselective NSAIDs--providing equivalent analgesic and anti-inflammatory efficacy. Their GI sparing is impaired by concomitant aspirin use, and concerns regarding adverse cardiovascular effects have emerged. Risk factors for NSAID-related complications include a history of ulcer disease or bleeding, concomitant corticosteroid or anticoagulant therapy, use of high-dose or multiple NSAIDs… CONTINUE READING
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