Prevention of N-methyl-N ′-nitro-N-nitrosoguanidine and saturated sodium chloride-induced gastric carcinogenesis in Wistar rats by lycopene

@article{Velmurugan2002PreventionON,
  title={Prevention of N-methyl-N ′-nitro-N-nitrosoguanidine and saturated sodium chloride-induced gastric carcinogenesis in Wistar rats by lycopene},
  author={B. Velmurugan and V. Bhuvaneswari and U. K. Burra and S. Nagini},
  journal={European Journal of Cancer Prevention},
  year={2002},
  volume={11},
  pages={19-26}
}
  • B. Velmurugan, V. Bhuvaneswari, +1 author S. Nagini
  • Published 2002
  • Chemistry, Medicine
  • European Journal of Cancer Prevention
  • We investigated "the "chemopreventive potential of lycopene against gastric carcinogenesis induced in male Wistar rats by N-methyl-N ′-nitro-N-nitrosoguanidine (MNNG) and saturated sodium chloride (S-NaCl). Administration of lycopene inhibited MNNG+S-NaCl-induced gastric carcinogenesis as revealed by the absence of carcinomas. Lipid peroxidation, reduced glutathione (GSH), glutathione peroxidase (GPx), glutathione S-transferase (GST) and glutathione reductase (GR) were used to monitor the… CONTINUE READING
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