Prevention of N‐Methylnitrosourea‐induced Colon Carcinogenesis in F344 Rats by Lycopene and Tomato Juice Rich in Lycopene

@inproceedings{Narisawa1998PreventionON,
  title={Prevention of N‐Methylnitrosourea‐induced Colon Carcinogenesis in F344 Rats by Lycopene and Tomato Juice Rich in Lycopene},
  author={Tomio Narisawa and Yoko Fukaura and Makiko Hasebe and Seiko Nomura and Shunji Oshima and Hideki Sakamoto and Takahiro Inakuma and Yukio Ishiguro and Junko Takayasu and Hoyoku Nishino},
  booktitle={Japanese journal of cancer research : Gann},
  year={1998}
}
Epidemiological studies have suggested a protective effect of lycopene and lycopene-rich tomatoes against various cancers. Here, the inhibition of colon carcinogenesis by lycopene and tomato juice was investigated. Seven-week-old female F344/NSlc rats received an intrarectal dose of 2 mg (experiment I) or 4 mg (experiment II) of N-methylnitrosourea 3 times a week for 3 weeks, and had free access to one of 4 drinking fluids: plain water (control group), 17 ppm lycopene water solution (Ly group… CONTINUE READING
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