Prevention of Murine Graft-Versus-Host Disease and Bone Marrow Alloengraftment Across the Major Histocompatibility Barrier After Donor Graft Preincubation With Anti-LFAl Immunotoxin

Abstract

We have investigated the effects of the in vitro depletion of LFAl positive cytolytic T lymphocytes, natural killer (NK) cells, and monocytes on the afferent phase of graft-versushost disease (GVHD). Lethal GVHD was induced across the murine major histocompatibility complex by injecting C57BL/6 (H-2b) bone marrow (BM) cells (a source of stem cells) and… (More)

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