Prevention of Intractable Partial Seizures by Intermittent Vagal Stimulation in Humans: Preliminary Results

  title={Prevention of Intractable Partial Seizures by Intermittent Vagal Stimulation in Humans: Preliminary Results},
  author={J. Kiffin Penry and J. Christine Dean},
Summary: Intermittent stimulation of the vagus nerve in four patients resulted in complete seizure control in two, a 40% reduction of seizure frequency in one, and no change in seizure frequency in the other. Side effects (hoarseness, stimulation sensation in the neck, and hiccups) were transient and occurred concomitantly with stimulation. All patients tolerated increasing stimulation parameters well. The results, however, are inconclusive because of the brief duration (6–12 months) of follow… 

Treatment of epilepsy by stimulation of the vagus nerve

Most patients tolerated the device and stimulation well, and two patients have been seizure-free for over 1 year and some cases of medically refractory partial seizures are improved by vagal stimulation.

Vagus nerve stimulation for epilepsy

  • D. Labar
  • Medicine, Psychology
    Clinical Neuroscience Research
  • 2004

Treatment of Refractory Partial Seizures: Preliminary Results of a Controlled Study

It is demonstrated that vagus nerve stimulation is a safe and effective method of treating partial epileptic seizures and ratings of the patient's overall condition, the patient, investigator, and companion as a measurement of “quality of life” also show improvement in the HIGH group.

Vagus nerve stimulation therapy for partial-onset seizures

Vagus nerve stimulation is an effective and safe adjunctive treatment for patients with refractory partial-onset seizures and represents the advent of a new, nonpharmacologic treatment for epilepsy.

Therapeutic Outcomes of Vagus Nerve Stimulation in Intractable Childhood Epilepsy

VNS might be an effective adjunctive therapy for intractable childhood epilepsy and transient side effects can be controlled without discontinuation of VNS therapy.

Vagus Nerve Stimulation for Treatment of Partial Seizures: 1. A Controlled Study of Effect on Seizures

The effectiveness of VNS as treatment for epilepsy patients with refractory partial seizures was confirmed and high VNS was more effective in reducing partial seizure frequency than was low VNS.

Optimization of epilepsy treatment with vagus nerve stimulation

VNS has been approved by the FDA since July 1997 for the adjunctive treatment of intractable partial onset epilepsy with and without secondary generalization in patients twelve years of age or older and the safety and efficacy have been proven and duplicated in two subsequent double‐blinded controlled studies.

[Vagal stimulation in the treatment of epilepsy].

The vagal nerve stimulation seems reasonable as a treatment for patients with difficult epilepsies, especially when the response to the antiepileptic drugs is poor or they are producing secondary effects, and the resection of the focus is not possible.

Stimulation of the Nervous System for the Management of Seizures

Deep brain stimulation is a new method for controlling medically refractory seizures based on the observation that thalamic stimulation can influence the EEG over a wide area and it has undergone trials in patients with depression.



Clinical and Physiological Effects of Stimulation of the Paleocerebellum in Humans

Chronically implanted electrodes allowed the repeated stimulation, with different rates and intensities and for variable durations, of the paleocerebellum in 4 patients with intractable muscular

The trigeminal, facial, vagal, and glossopharyngeal nerves in the monkey. Afferent connections.

The Nauta-Gygax technique was selected because it demonstrates degenerating nonmyelinated as well as myelinated axons and because it had not been used to trace the entering afferents of VII, IX and X in the monkey.

Experimental study of the projections of the nucleus of the tractus solitarius and the area postrema in the cat

Evidence is given to support the hypothesis that ascening visceral pathways are interruped in the bulbar reticular formation and dorsal tegmental nucleus before reaching the diencephalon as well as with functional aspects of the central autonomic and reticular activating systems.

The effect of vagal afferent stimulation on the EEG pattern of the cat.