Prevention of I/R injury in fatty livers by ischemic preconditioning is associated with increased mitochondrial tolerance: the key role of ATPsynthase and mitochondrial permeability transition.

@article{Rolo2009PreventionOI,
  title={Prevention of I/R injury in fatty livers by ischemic preconditioning is associated with increased mitochondrial tolerance: the key role of ATPsynthase and mitochondrial permeability transition.},
  author={Anabela Pinto Rolo and Jo{\~a}o Soeiro Teodoro and Carmen Peralta and Joan Rosell{\'o}-Catafau and Carlos Manuel Marques Palmeira},
  journal={Transplant international : official journal of the European Society for Organ Transplantation},
  year={2009},
  volume={22 11},
  pages={1081-90}
}
Ischemia/reperfusion (I/R) injury is a commonly encountered clinical problem and occurs probably as a consequence of irreversible mitochondrial injury. The increased susceptibility of fatty livers to ischemic injury is associated with depletion of adenosine triphosphate (ATP) content, which is preserved by preconditioning. Mitochondria being the main ATP production source for the cell, we aimed to evaluate whether ischemic preconditioning (IPC) of fatty livers prevents the impairment in… CONTINUE READING

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