Prevention of HIF-1 activation and iNOS gene targeting by low-dose cadmium results in loss of myocardial hypoxic preconditioning in the rat.

@article{Belaidi2008PreventionOH,
  title={Prevention of HIF-1 activation and iNOS gene targeting by low-dose cadmium results in loss of myocardial hypoxic preconditioning in the rat.},
  author={Elise Belaidi and Pauline C. B{\'e}guin and Patrick A. Levy and Christophe Ribuot and Diane Godin-Ribuot},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2008},
  volume={294 2},
  pages={
          H901-8
        }
}
This study aimed to underline the interaction between hypoxia-inducible factor-1 (HIF-1) and the inducible nitric oxide synthase (iNOS) gene in vivo and their contribution to the delayed myocardial preconditioning induced by acute intermittent hypoxia (IH) in the rat using chromatin immunoprecipitation and pharmacological inhibition by low-dose cadmium. Langendorff-perfused hearts of Wistar rats exposed to normoxia or IH 24 h earlier were submitted to global ischemia and reperfusion. Effects of… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 34 REFERENCES

The late phase of preconditioning.

  • Circulation research
  • 2000
VIEW 8 EXCERPTS
HIGHLY INFLUENTIAL

Surviving ischemia: adaptive responses mediated by hypoxia-inducible factor 1.

  • The Journal of clinical investigation
  • 2000
VIEW 3 EXCERPTS
HIGHLY INFLUENTIAL

The ubiquitous role of nitric oxide in cardioprotection.

  • Journal of molecular and cellular cardiology
  • 2006
VIEW 1 EXCERPT