Prevention of Group B Streptococcal Early-Onset Disease in Newborns: ACOG Committee Opinion, Number 782.

  title={Prevention of Group B Streptococcal Early-Onset Disease in Newborns: ACOG Committee Opinion, Number 782.},
  journal={Obstetrics and gynecology},
  volume={134 1},
  • Published 2019
  • Medicine
  • Obstetrics and gynecology
Group B streptococcus (GBS) is the leading cause of newborn infection. The primary risk factor for neonatal GBS early-onset disease (EOD) is maternal colonization of the genitourinary and gastrointestinal tracts. Approximately 50% of women who are colonized with GBS will transmit the bacteria to their newborns. Vertical transmission usually occurs during labor or after rupture of membranes. In the absence of intrapartum antibiotic prophylaxis, 1-2% of those newborns will develop GBS EOD. Other… 

Management of Infants at Risk for Group B Streptococcal Disease

The American Academy of Pediatrics joins with the American College of Obstetricians and Gynecologists to reaffirm the use of universal antenatal microbiologic-based testing for the detection of maternal GBS colonization to facilitate appropriate administration of intrapartum antibiotic prophylaxis.

Group B Streptococcus colonization at delivery is associated with maternal peripartum infection

GBS colonization at delivery is associated with increased risk of peripartum infection, whether this increase is due directly to invasion by GBS or whether GBS colonization isassociated with a more general vulnerability to infection remains to be determined.

Group B Streptococcal Colonization among Pregnant Women and Neonates in a Tertiary Care Hospital in South India

Maternal GBS colonization was significantly associated with premature rupture of membrane and high maternal colonization alerts the need for GBS screening in India, andClindamycin resistance among GBS isolates questions its effectiveness as alternative therapy in penicillin allergy.

Outcomes in reported penicillin allergic mothers and neonates requiring Group B streptococcal prophylaxis: a retrospective observational cohort study

In hospitalized obstetric patients, a PcnA label was associated with a shorter maternal course of antibiotic treatment and a longer neonatal LOS, and further prospective studies are needed to clarify the underlying reasons for these outcomes.

Regional Variation of Early-onset Neonatal Group B Streptococcal Disease Prevention Strategies in Mainland China.

Different strategies for preventing EOGBS may be needed in different regions of mainland China, and screening strategies may be most appropriate in regions with higher attack rates, even with moderate levels of maternal GBS colonization.

Intrapartum group B Streptococcal prophylaxis and childhood weight gain

GBS-specific IAP was associated with a modest increase in rate of early childhood weight gain and these findings highlight the need to better understand effects of intrapartum antibiotic exposure on childhood growth and support efforts to develop alternate prevention strategies.

Group B streptococcal infection of the genitourinary tract in pregnant and non-pregnant patients with diabetes mellitus: an immunocompromised host or something more?

The evolving epidemiology, immunology, and pathophysiology of GBS urogenital infections including rectovaginal colonization during pregnancy, neonatal infections of infants exposed to DM in utero, and urinary tract infections in pregnant and non-pregnant adults in the context of DM are reviewed.

Comparison of the Panther Fusion and BD MAX Group B Streptococcus (GBS) Assays for Detection of GBS in Prenatal Screening Specimens

The Panther Fusion GBS assay has clinical performance comparable to that of the BD MAX G BS assay but provides a faster TAT, less HoT, and higher throughput.

Middle-East OBGYN Graduate Education (MOGGE) Foundation practice guidelines: prevention of group B Streptococcus infection in pregnancy and in newborn. Practice guideline no. 02-O-20.

  • S. ShazlyA. Radwan Mostafa H Abouzeid
  • Medicine
    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
  • 2021
This guideline appraises current evidence on screening and management of GBS colonization in pregnancy particularly in low-resource settings.



Perinatal infections due to group B streptococci.

The epidemiology, diagnosis, and therapy of GBS perinatal infection is reviewed, including implementation of new diagnostic techniques, management of preterm rupture of membranes, use of alternative antibiotic approaches, improvement of compliance, prevention of low birth weight infants, emergence of resistant organisms, and vaccine development.

Risk of Early-Onset Neonatal Group B Streptococcal Disease With Maternal Colonization Worldwide: Systematic Review and Meta-analyses

  • N. RussellA. Seale C. Baker
  • Medicine
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
  • 2017
The risk of EOGBS among GBS-colonized pregnant women, from this first systematic review, is consistent with previous estimates from single studies (1%–2%).

Prevention of early‐onset neonatal group B streptococcal disease with selective intrapartum chemoprophylaxis

Early-Onset Group B Streptococcal Disease in the United States: Potential for Further Reduction

It is estimated that under optimal implementation, cases of early-onset GBS disease could be reduced by 26–59% with the largest benefit from a single intervention coming from improved use of intrapartum prophylaxis (16% decrease).

Group B streptococcal bacteriuria during pregnancy as a risk factor for maternal intrapartum colonization: a prospective cohort study

GBS bacteriuria is a risk factor for IPC, irrespective of urinary GBS concentration or of colonization status at late gestation, and microbiology laboratories should search, and report, GBS of any colony count in urine from pregnant women, and not only in the presence of ≥104 c.u.f. ml−1 as the 2010 CDC guidelines recommend.

Duration of Intrapartum Antibiotics for Group B Streptococcus on the Diagnosis of Clinical Neonatal Sepsis

Treatment with ≥4 hours of IAP reduced the risk of infants being diagnosed with clinical sepsis by 65%, adjusted relative risk 0.35, CI 0.16–0.79, and P = .01.

Prevention of Perinatal Group B Streptococcal Disease

The 2002 Prevention of Perinatal Group B Streptococcal Disease guidelines from the Center for Disease Control represents a revision of a prior set of guidelines represented by the CDC in 1996, and included a recommendation for universal prenatal screening for GBS.

Neonatal septicemia due to group B streptococci — Perinatal risk factors and outcome of subsequent pregnancies

Screening of parturients at risk and selective antibiotic prophylaxis may help to prevent early onset GBS-septicemia.

Timing of Group B Streptococcus Screening in Pregnancy: A Systematic Review

Recommendations to screen pregnant women for colonization of GBS at 35–37 weeks’ gestation are confirmed, but one should be aware of the limitations of screening, with 6% of G BS carriers remaining undetected in antenatal cultures.