Prevention of GVHD and graft rejection by a new S1P receptor agonist, W-061, in rat small bowel transplantation.


BACKGROUND In small bowel transplantation (SBTx), inhibition of both graft-versus-host disease (GVHD) and allograft rejection is necessary. METHODS We investigated the potency of a new sphingosine-1-phosphate receptor agonist, W-061, for these two immune responses in SBTx. W-061 has a completely different molecular structure from FTY720. Heterotopic SBTx… (More)
DOI: 10.1016/j.trim.2011.12.005