Prevention of Dabigatran-Related Gastrointestinal Bleeding With Gastroprotective Agents: A Population-Based Study.

@article{Chan2015PreventionOD,
  title={Prevention of Dabigatran-Related Gastrointestinal Bleeding With Gastroprotective Agents: A Population-Based Study.},
  author={Esther W Chan and Wallis C. Y. Lau and Wai Keung Leung and Michael Mok and Ying He and Teresa S M Tong and Ian Chi Kei Wong},
  journal={Gastroenterology},
  year={2015},
  volume={149 3},
  pages={586-95.e3}
}
BACKGROUND & AIMS Use of dabigatran, an inhibitor of thrombin, increases the risk of gastrointestinal bleeding (GIB). However, it is not clear whether gastroprotective agents (GPAs) prevent GIB in dabigatran users. We investigated the risk of GIB and the role of gastroprotective agents (including proton pump inhibitors and histamine type-2-receptor antagonists) in patients using dabigatran. METHODS We performed a retrospective cohort study using a population-wide database managed by the Hong… CONTINUE READING