Prevention of Brca1-mediated mammary tumorigenesis in mice by a progesterone antagonist.

@article{Poole2006PreventionOB,
  title={Prevention of Brca1-mediated mammary tumorigenesis in mice by a progesterone antagonist.},
  author={Aleksandra Jovanovic Poole and Ying Li and Yoon Kim and S Joyce Lin and Wen-Hwa Lee and Eva Y-H P Lee},
  journal={Science},
  year={2006},
  volume={314 5804},
  pages={1467-70}
}
Women with mutations in the breast cancer susceptibility gene BRCA1 are predisposed to breast and ovarian cancers. Why the BRCA1 protein suppresses tumor development specifically in ovarian hormone-sensitive tissues remains unclear. We demonstrate that mammary glands of nulliparous Brca1/p53-deficient mice accumulate lateral branches and undergo extensive alveologenesis, a phenotype that occurs only during pregnancy in wild-type mice. Progesterone receptors, but not estrogen receptors, are… CONTINUE READING
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