Prevention of Bleomycin-Induced Lung Fibrosis in Mice by a Novel Approach of Parallel Inhibition of Cyclooxygenase and Nitric-Oxide Donation Using NCX 466, a Prototype Cyclooxygenase Inhibitor and Nitric-Oxide Donor

@article{Pini2012PreventionOB,
  title={Prevention of Bleomycin-Induced Lung Fibrosis in Mice by a Novel Approach of Parallel Inhibition of Cyclooxygenase and Nitric-Oxide Donation Using NCX 466, a Prototype Cyclooxygenase Inhibitor and Nitric-Oxide Donor},
  author={A. Pini and S. Viappiani and M. Bolla and E. Masini and D. Bani},
  journal={Journal of Pharmacology and Experimental Therapeutics},
  year={2012},
  volume={341},
  pages={493 - 499}
}
  • A. Pini, S. Viappiani, +2 authors D. Bani
  • Published 2012
  • Chemistry, Medicine
  • Journal of Pharmacology and Experimental Therapeutics
  • Cyclooxygenase (COX)-inhibiting nitric oxide (NO) donors (CINODs) are designed to inhibit COX-1 and COX-2 while releasing NO. COX inhibition is responsible for anti-inflammatory and pain-relieving effects, whereas NO donation can improve microcirculation and exert anti-inflammatory and antioxidant actions. In an in vivo mouse model of bleomycin-induced lung fibrosis, we evaluated whether a prototype CINOD compound, (S)-(5S)-5,6-bis(nitrooxy)hexyl)2-(6-methoxynaphthalen-2-yl)propanoate (NCX 466… CONTINUE READING
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    References

    SHOWING 1-10 OF 37 REFERENCES
    Anti-fibrotic effect of meloxicam in a murine lung fibrosis model.
    • 48
    The effect of diclofenac acid (Voltaren) on bleomycin-induced pulmonary fibrosis in hamsters.
    • 6
    Reduction of antigen-induced respiratory abnormalities and airway inflammation in sensitized guinea pigs by a superoxide dismutase mimetic.
    • 60
    Bleomycin-induced pulmonary fibrosis in the rat: inhibition by indomethacin.
    • 286
    GM-CSF Regulates Bleomycin-Induced Pulmonary Fibrosis Via a Prostaglandin-Dependent Mechanism
    • 141
    • PDF