Prevention of Autoimmunity by Targeting a Distinct, Noninvariant CD1d-reactive T Cell Population Reactive to Sulfatide

@article{Jahng2004PreventionOA,
  title={Prevention of Autoimmunity by Targeting a Distinct, Noninvariant CD1d-reactive T Cell Population Reactive to Sulfatide},
  author={Alex W. Jahng and Igor Maricic and Cristian Aguilera and Susanna L Cardell and Ramesh Chandra Halder and Vipin Kumar},
  journal={The Journal of Experimental Medicine},
  year={2004},
  volume={199},
  pages={947 - 957}
}
Class I and class II MHC-restricted T cells specific for proteins present in myelin have been shown to be involved in autoimmunity in the central nervous system (CNS). It is not yet known whether CD1d-restricted T cells reactive to myelin-derived lipids are present in the CNS and might be targeted to influence the course of autoimmune demyelination. Using specific glycolipid-CD1d tetramers and cloned T cells we have characterized a T cell population reactive to a myelin-derived glycolipid… CONTINUE READING

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