Prevention of Autoimmune Diabetes by Ectopic Pancreatic β-Cell Expression of Interleukin-35

@inproceedings{Bettini2012PreventionOA,
  title={Prevention of Autoimmune Diabetes by Ectopic Pancreatic β-Cell Expression of Interleukin-35},
  author={Maria Bettini and Ashley H. Castellaw and Greig Patrick Lennon and Amanda Burton and Dario A. A. Vignali},
  booktitle={Diabetes},
  year={2012}
}
Interleukin (IL)-35 is a newly identified inhibitory cytokine used by T regulatory cells to control T cell-driven immune responses. However, the therapeutic potential of native, biologically active IL-35 has not been fully examined. Expression of the heterodimeric IL-35 cytokine was targeted to β-cells via the rat insulin promoter (RIP) II. Autoimmune… CONTINUE READING